Strong minor groove base conservation in sequence logos implies DNA distortion or base flipping during replication and transcription initiation
نویسندگان
چکیده
منابع مشابه
Strong minor groove base conservation in sequence logos implies DNA distortion or base flipping during replication and transcription initiation.
The sequence logo for DNA binding sites of the bacteriophage P1 replication protein RepA shows unusually high sequence conservation ( approximately 2 bits) at a minor groove that faces RepA. However, B-form DNA can support only 1 bit of sequence conservation via contacts into the minor groove. The high conservation in RepA sites therefore implies a distorted DNA helix with direct or indirect co...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2001
ISSN: 1362-4962
DOI: 10.1093/nar/29.23.4881